Last updated 1 month ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Possible
35465336
\"Parasites that carry a deletion of MaCFET (Pfmacfet¯), developed normally as asexual stages, indicating that its function is not essential for the asexual proliferation of the parasite in vitro. Furthermore, Pfmacfet¯ male and female gametocytes developed normally and underwent activation to form microgametes and macrogametes. However, by utilizing genetic crosses, we demonstrate that Pfmacfet¯ parasites suffer a complete female-specific defect in successful fertilization. Therefore, PfMaCFET is a critical female-contributed factor for parasite transmission to the mosquito.\"
Theo Sanderson, Francis Crick Institute
P. berghei ANKA
Possible
RMgm-5069 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
35465336
\"Parasites that carry a deletion of MaCFET (Pfmacfet¯), developed normally as asexual stages, indicating that its function is not essential for the asexual proliferation of the parasite in vitro. Furthermore, Pfmacfet¯ male and female gametocytes developed normally and underwent activation to form microgametes and macrogametes. However, by utilizing genetic crosses, we demonstrate that Pfmacfet¯ parasites suffer a complete female-specific defect in successful fertilization. Therefore, PfMaCFET is a critical female-contributed factor for parasite transmission to the mosquito.\"
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
Attenuated
35465336
\"Parasites that carry a deletion of MaCFET (Pfmacfet¯), developed normally as asexual stages, indicating that its function is not essential for the asexual proliferation of the parasite in vitro. Furthermore, Pfmacfet¯ male and female gametocytes developed normally and underwent activation to form microgametes and macrogametes. However, by utilizing genetic crosses, we demonstrate that Pfmacfet¯ parasites suffer a complete female-specific defect in successful fertilization. Therefore, PfMaCFET is a critical female-contributed factor for parasite transmission to the mosquito.\"
Theo Sanderson, Francis Crick Institute
P. berghei ANKA Asexual
No difference
RMgm-5069 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-5069
Infertile females, fertile males.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-5069
Infertile females, fertile males.Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-5069
Complete (or nearly complete) loss in the ability to form oocysts in mosquitoes
Imported from RMgmDB

More information

PlasmoDB PF3D7_1241400
GeneDB PF3D7_1241400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) 2277.t00398, MAL12P1.396, PFL1990c
Orthologs PBANKA_1454800 , PCHAS_1457100 , PKNH_1460500 , PVP01_1458500 , PVX_100970 , PY17X_1457300
Google Scholar Search for all mentions of this gene