Last updated 2 months ago

Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) Imported from PlasmoGEM
P. berghei ANKA
Possible
RMgm-4189 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Altered cytoadherence
https://www.nature.com/articles/ncomms16044 (Knock down)
Viable upon knockdown with no growth rate difference in vitro. But decreased binding to CD36, less deformability, and less protein export.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) Imported from PlasmoGEM
P. berghei ANKA Asexual
Difference from wild-type
RMgm-4189
Growth and multiplication of blood stages in mice comparable to wild type parasites. Two separate clones of mice infected with PbDPV1 parasites succumbed to cerebral malaria 24 days later than mice infected with wild-type PbANKA (PbANKA 57 days post infection, PbDPV1 79 days post infection).
Imported from RMgmDB

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