Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4657 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4657 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-4657
Normal gametocyte production. Activation of female gametocytes normal. Male exflagellation, however, strongly reduced. Flagella stained with an anti-tubulin antibody remain curled within the gametocyte body. Motility of male free gametes strongly impaired.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4657
Ablation of PbSR-MG also resulted in fewer oocysts per mosquito host. To test if this difference solely reflected the defect in exflagellation, we repeated the mosquito infection using equal numbers of in vitro generated ookinetes. Despite exposing mosquitoes to equal infective load, we still observed a significant difference in oocyst numbers in PbSR-MG KO compared to wild-type parental parasites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-4657 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-4657 Imported from RMgmDB

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