Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4594 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-4594
Growth of asexual blood stages is normal in the presence of pABA in diet of mice. In milk-fed mice adcs- parasite propagation was severely impaired, whereas WT parasites displayed normal growth. Upon pABA supplementation via the drinking water, adcs- growth was fully restored, and mutant parasites grew indistinguishable from WT in milk-fed mice.Continued pABA restriction led to the retraction of adcs- parasitemia from day 12 onward, which was immediately reverted upon addition of pABA on day 18. During more extended periods of pABA deficiency, adcs- parasitemia dropped below the detection threshold, followed by alternating periods of re-emergence and retraction, indicative of latent malaria infection.
Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4594 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-4594 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-4594 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-4594 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-4594 Imported from RMgmDB

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