Last updated 4 months ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
28842684
Decreased parasitaemia and metacaspase expression on exposure to sodium nitroprusside. The protein appears to play a role in volume regulation.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
28842684
Decreased parasitaemia and metacaspase expression on exposure to sodium nitroprusside. The protein appears to play a role in volume regulation.
Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

Intraerythrocytic expression of PfSR25 and gene disruption. IFA of PfSR25 during erythrocyte stages was done at ring; trophozoite; schizont and merozoite stage. PfMSP1 was used to confirm the co-localization of SR25. PfSR25 was clearly detected in RBC infective parasite stage, i.e. the merozoite. Co-localization with Plasmodium surface protein MSP-1 reveals that SR25 expression at parasite membrane.Moraes MS, Budu A, Singh MK, Borges-Pereira L, Levano-Garcia J, CurrĂ  C, Picci L, Pace T, Ponzi M, Pozzan T, Garcia CRS. Plasmodium falciparum GPCR-like receptor SR25 mediates extracellular K(+) sensing coupled to Ca(2+) signaling and stress survival. Sci Rep. 2017 7(1):9545.

See original on MMP

More information