Last updated 2 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA
Refractory
RMgm-739 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-738 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-566 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-483 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) Imported from PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Localization and co-localization of PfPK4, RAP-1, PF14_0102, PF83/AMA-1 PF11_0344 and MSP1 PFI1475w. (A) A segmenter, stained for PfPK4 (red) and RAP-1 (green), with a composite of both labels on the right ; (B) schizont ; (C) segmenter ; (D) and (E) free merozoites, stained for PfPK4 (red) and PF83/AMA-1 (green), with composites on the right ; (F) a free merozoite, a composite of PfPK4 (red) and RAP-1 (green); (G) free merozoites stained for PfPK4 (red) and MSP-1 (green), with a composite of both labels on the right. The scale bars represent 2 mm. PfPK4 distributed throughout the trophozoite, whereas it was found in discrete foci (punctate distribution) in segmenters. PfPK4 co-localizes with AMA-1 at the apical complex in segmenters and merozoites, but does not co-localize with RAP-1.Reproduced with permission, from Möhrle JJ, Zhao Y, Wernli B, Franklin RM, Kappes B. Molecular cloning, characterization and localization of PfPK4, an eIF-2a kinase-related enzyme from the malarial parasite Plasmodium falciparum. Biochem J. 1997 328:677-87. © the Biochemical Society.

See original on MMP

More information

PlasmoDB PF3D7_0628200
GeneDB PF3D7_0628200
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) 2270.t00170, MAL6P1.146, PFF1370w
Orthologs PBANKA_1126900 , PCHAS_1126400 , PKNH_1121600 , PVP01_1121300 , PVX_114512 , PY17X_1128400
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