Last updated 2 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Refractory
RMgm-739 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-738 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-566 Imported from RMgmDB
P. berghei ANKA
Refractory
RMgm-483 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Localization and co-localization of PfPK4, RAP-1, PF14_0102, PF83/AMA-1 PF11_0344 and MSP1 PFI1475w. (A) A segmenter, stained for PfPK4 (red) and RAP-1 (green), with a composite of both labels on the right ; (B) schizont ; (C) segmenter ; (D) and (E) free merozoites, stained for PfPK4 (red) and PF83/AMA-1 (green), with composites on the right ; (F) a free merozoite, a composite of PfPK4 (red) and RAP-1 (green); (G) free merozoites stained for PfPK4 (red) and MSP-1 (green), with a composite of both labels on the right. The scale bars represent 2 mm. PfPK4 distributed throughout the trophozoite, whereas it was found in discrete foci (punctate distribution) in segmenters. PfPK4 co-localizes with AMA-1 at the apical complex in segmenters and merozoites, but does not co-localize with RAP-1.Reproduced with permission, from Möhrle JJ, Zhao Y, Wernli B, Franklin RM, Kappes B. Molecular cloning, characterization and localization of PfPK4, an eIF-2a kinase-related enzyme from the malarial parasite Plasmodium falciparum. Biochem J. 1997 328:677-87. © the Biochemical Society.

See original on MMP

More information

PlasmoDB PF3D7_0628200
GeneDB PF3D7_0628200
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) 2270.t00170, MAL6P1.146, PFF1370w
Orthologs PBANKA_1126900 , PCHAS_1126400 , PKNH_1121600 , PVP01_1121300 , PVX_114512 , PY17X_1128400
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