PF3D7_0618500 malate dehydrogenase (MDH)
Disruptability [+]
| Species | Disruptability | Reference | Submitter | |
|---|---|---|---|---|
| P. falciparum 3D7 |
Refractory |
USF piggyBac screen (Insert. mut.) | USF PiggyBac Screen | |
| P. berghei ANKA |
Possible |
RMgm-1272 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
RMgm-1273 | Imported from RMgmDB | |
| P. berghei ANKA |
Possible |
PlasmoGEM (Barseq) | PlasmoGEM | |
Mutant phenotypes [+]
| Species | Stage | Phenotype | Reference | Submitter |
|---|---|---|---|---|
| P. berghei ANKA | Asexual |
Difference from wild-type |
RMgm-1272
Normal growth/multiplication of asexual blood stages |
Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Difference from wild-type |
RMgm-1273
Normal growth/multiplication of asexual blood stages |
Imported from RMgmDB |
| P. berghei ANKA | Asexual |
Attenuated |
PlasmoGEM (Barseq) | PlasmoGEM |
| P. berghei ANKA | Gametocyte |
Difference from wild-type |
RMgm-1272
Normal gametocyte production. Reduced formation of gametes |
Imported from RMgmDB |
| P. berghei ANKA | Gametocyte |
Difference from wild-type |
RMgm-1273
Normal gametocyte production. Reduced formation of gametes |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-1272
Reduced ookinete formation (50%) |
Imported from RMgmDB |
| P. berghei ANKA | Ookinete |
Difference from wild-type |
RMgm-1273
Reduced ookinete formation (50%) |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-1272
Reduced oocyst formation |
Imported from RMgmDB |
| P. berghei ANKA | Oocyst |
Difference from wild-type |
RMgm-1273
Reduced oocyst formation |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-1272
Sporozoites are formed that are infective to mice. No details on the numbers. |
Imported from RMgmDB |
| P. berghei ANKA | Sporozoite |
Difference from wild-type |
RMgm-1273
Sporozoites are formed that are infective to mice. No details on the numbers. |
Imported from RMgmDB |
Imaging data (from Malaria Metabolic Pathways)
Immunolocalization of MDH in erythrocytes infected with Plasmodium falciparum. A Bright light image - infected and uninfected erythrocytes. B Red fluorescent image - distribution of MDH protein in the infected erythrocytes. C Blue fluorescent image - nucleus of malaria parasite stained with DAPI. D Merged image – shows cytoplasmic localization of MDH protein within the intraerythrocytic malaria parasites.Pradhan A, Mukherjee P, Tripathi AK, Avery MA, Walker LA, Tekwani BL. Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants. Mol Cell Biochem. 2009 325(1-2):141-8.
See original on MMPMore information
| PlasmoDB | PF3D7_0618500 |
| GeneDB | PF3D7_0618500 |
| Malaria Metabolic Pathways | Localisation images Pathways mapped to |
| Previous ID(s) | 2270.t00073, MAL6P1.242, PFF0895w |
| Orthologs | PBANKA_1117700 , PCHAS_1117200 , PKNH_1131900 , PVP01_1131000 , PVX_114050 , PY17X_1118800 |
| Google Scholar | Search for all mentions of this gene |