Last updated 1 month ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
30133543
Normal gametocyte formation. Males activate and become motile. Number of macrogametes and zygotes reduced. Deregulation of components required for protein synthesis.
Theo Sanderson, Google AI
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
30133543
Normal gametocyte formation. Males activate and become motile. Number of macrogametes and zygotes reduced. Deregulation of components required for protein synthesis.
Theo Sanderson, Google AI
P. falciparum 3D7 Gametocyte
Attenuated
30133543
Normal gametocyte formation. Males activate and become motile. Number of macrogametes and zygotes reduced. Deregulation of components required for protein synthesis.
Theo Sanderson, Google AI
P. falciparum 3D7 Ookinete
Attenuated
30133543
Normal gametocyte formation. Males activate and become motile. Number of macrogametes and zygotes reduced. Deregulation of components required for protein synthesis.
Theo Sanderson, Google AI
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Immunofluorescence localisation of LANCL1 in uninfected and P. falciparum-infected erythrocytes. Un-infected erythrocytes and P. falciparum-infected erythrocytes at different stages of the parasite intra-erythrocytic cycle were fixed and permeabilized. Immunofluorescence analyses were performed using the rabbit H60 LANCL1-specific serum, and a mouse serum raised against the carboxy-terminal domain of PfSBP1. DAPI staining of the nuclei assessed the stage of the intra-erythrocytic parasite (in blue). In uninfected erythrocytes (a) and early trophozoites (b) a pattern consistent with a cytosolic localization and spots of aggregation of LANCL1 is observed. In P. falciparum schizonts (c), an additional labelling similar to that obtained with PfSBP1-specific antibodies (g and h) is observed, suggesting a Maurer’s cleft-like localization of LANCL1.Blisnick T, Vincensini L, Barale JC, Namane A, Braun Breton C. LANCL1, an erythrocyte protein recruited to the Maurer's clefts during Plasmodium falciparum development. Mol Biochem Parasitol. 2005 141:39-47. Copyright Elsevier 2010.

See original on MMP

More information

PlasmoDB PF3D7_0525400
GeneDB PF3D7_0525400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL5P1.253, PFE1265w
Orthologs PBANKA_1240200 , PCHAS_1240600 , PKNH_1007400 , PVP01_1008400 , PVX_079975 , PY17X_1243400
Google Scholar Search for all mentions of this gene