Last updated 5 months ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4173 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-4458 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
No difference
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Gametocyte
No difference
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Ookinete
Attenuated
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Oocyst
Attenuated
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4173 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-4458 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4173 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4458 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-4173 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4173
Normal ookinete production. Normal ookinete motility. Significantly reduced oocyst numbers/production.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4173
Normal ookinete production. Significantly reduced oocyst numbers/production.Significantly reduced salivary gland numbers/production. Sporozoites were infective to mice as shown by bite-back experiments
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4173
Significantly reduced salivary gland numbers/production. Sporozoites were infective to mice as shown by bite-back experiments
Imported from RMgmDB

More information

PlasmoDB PF3D7_0507300
GeneDB PF3D7_0507300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL5P1.74, PFE0360c
Orthologs PBANKA_1106900 , PCHAS_1106600 , PKNH_1026300 , PVP01_1026700 , PVX_097925 , PY17X_1108000
Google Scholar Search for all mentions of this gene