Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Co-localization assays of PfSUMO antiserum with nuclear marker PfSir2, cytoplasmic marker, PfHsp70-1 and Maurer’s clefts marker, Pf332 reveal compartmentalization. Size bar corresponds to 1 mm.Issar N, Roux E, Mattei D, Scherf A. Identification of a novel post-translational modification in Plasmodium falciparum: protein sumoylation in different cellular compartments. Cell Microbiol. 2008 10:1999-2011.

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Sumoylation is differentially regulated during P. falciparum red blood cell stages. Indirect immunofluorescence microscopy of synchronized 3D7 parasites probed with anti-PfSUMO mAb 7E11 and anti-ACP antibodies. DNA was detected using DAPI. Bar indicates 2 μm. SUMO was concentrated in the nucleus of parasites at all three stages, with no discernible association with Maurer’s clefts. Consistent with immunoblot analysis, levels of detectable SUMO signal were greatest in trophozoite and schizont stage parasites.Reiter K, Mukhopadhyay D, Zhang H, Boucher LE, Kumar N, Bosch J, Matunis MJ. Identification of Biochemically Distinct Properties of the Small Ubiquitin-related Modifier (SUMO) Conjugation Pathway in Plasmodium falciparum. J Biol Chem. 2013 Sep 27;288(39):27724-36. -

See original on MMP

More information

PlasmoDB PF3D7_0505800
GeneDB PF3D7_0505800
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL5P1.58, PFE0285c
Orthologs PBANKA_1105400 , PCHAS_1105100 , PKNH_1027800 , PVP01_1028200 , PVX_097850 , PY17X_1106500
Google Scholar Search for all mentions of this gene