Last updated 6 months ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Refractory
18614010 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
https://www.biorxiv.org/content/early/2017/10/13/202812
Point mutation and KO failed
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
RMgm-812 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Difference from wild-type
29509772 (Knock down)
glmS knockdown. Only very subtle growth defect seen and authors argue against role in egress.
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7 Asexual
Invasion defect
https://www.biorxiv.org/content/early/2017/10/13/202812 (Conditional)
DiCre approach. Substantially reduced invasion rate.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Asexual
Difference from wild-type
RMgm-812
Normal growth/multiplication of blood stages during the first 5-7 days after (mechanical) infection. Reduced complications of experimental cerebral malaria (ECM).
Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization. Apical. Nuclei were stained with DAPI (blue).Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.

See original on MMP

More information

PlasmoDB PF3D7_0404700
GeneDB PF3D7_0404700
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL4P1.45, PFD0225c, PFD0230c
Orthologs PBANKA_1002400 , PCHAS_1003300 , PKNH_0302800 , PVP01_0304100 , PVX_001005 , PY17X_1003800
Google Scholar Search for all mentions of this gene