Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4684 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4684 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4684 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-4684 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4684
No significant difference in the number of kinesin-8X oocysts compared to wild-type controls at 7 dpi (days post-infection), but by 10 dpi we observed a significant reduction in mutant oocysts, which became even more significant at 14 dpi. By 21 dpi the number of GFP-positive kinesin-8X oocysts had decreased further to only 810% of the WT-GFP number. We also detected a significant decrease in the size of the kinesin-8X oocysts at 10, 14 and 21 dpi. At 21 dpi most of the kinesin-8X oocysts were dead, with diminished GFP expression and the presence of disintegrated nuclei. We also observed no viable sporozoites in these oocysts, and were unable to detect any salivary gland sporozoites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4684
We did not observed viable sporozoites in the oocysts, and were unable to detect any salivary gland sporozoites.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4684
No infection of mice by bite of infected mosquitoes
Imported from RMgmDB

More information

PlasmoDB PF3D7_0319400
GeneDB PF3D7_0319400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL3P7.1, PFC0860w
Orthologs PBANKA_0805900 , PCHAS_0806200 , PKNH_0821800 , PVP01_0820800 , PVX_095265 , PY17X_0809100
Google Scholar Search for all mentions of this gene