Last updated 2 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
RMgm-520 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-392 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-520 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-392 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-520 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-392 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-520 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-392
Ookinete formation is reduced. This result is not based on counting ookinetes in vitro or in vivo but on quantitative PCR analysis of levels of 18S rRNA in mosquito midguts.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-520
Oocyst numbers (day12-14) reduced to 50% of wild type
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-392
Numbers of oocyst and of midgut-derived sporozoites are reduced. Transmission electron microscopy analyses of oocysts did not reveal any morphological differences wild type and mutant oocysts.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-520
Salivary gland sporozoite numbers reduced to 10% of wild type
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-392
Numbers of oocyst and of midgut-derived sporozoites are reduced. A reduction (~75%)in the number of salivary gland sporozoites. Salivary gland sporozoites showed normal gliding motility, hepatocyte invasion, liver stage development and infectivity to mice.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-520
no transmission by mosquito bite
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-392
Numbers of oocyst and of midgut-derived sporozoites are reduced. A reduction (~75%)in the number of salivary gland sporozoites. Salivary gland sporozoites showed normal gliding motility, hepatocyte invasion, liver stage development and infectivity to mice.
Imported from RMgmDB

More information

PlasmoDB PF3D7_0311400
GeneDB PF3D7_0311400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL3P4.16, PFC0485w
Orthologs PBANKA_0409400 , PCHAS_0410300 , PY17X_0411900
Google Scholar Search for all mentions of this gene