Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4688 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4688 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4688 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-4688
Ookinete formation did not reveal a significant difference between mutant and WT parasite development with ookinete morphologies similar as revealed by Giemsa-stained smears and scanning electron microscopy analysis. Ookinetes were also formed in vivo as revealed by Giemsa stained smears of mosquito midguts formed 24 h after feeding on an infected mouse. Mature omd(-) ookinetes were completely devoid of productive motility; at most they displayed stretching of the ookinete.In vivo transmission experiments, where mosquitoes are allowed to blood feed on mice infected with the omd(-)cl1 mutant, did not result in the establishment of oocysts in three independent feedings; WT parasites on the other hand transmitted normally.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4688
In vivo transmission experiments, where mosquitoes are allowed to blood feed on mice infected with the omd(-)cl1 mutant, did not result in the establishment of oocysts in three independent feedings; WT parasites on the other hand transmitted normally.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4688
No oocyst and sporozoite formation
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4688
No oocyst and sporozoite formation. No transmission to mice by bite of infected mosquitoes.
Imported from RMgmDB

More information