Last updated 2 years ago

Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA
Possible
RMgm-532 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-482 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-532 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-482 Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) Imported from PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-532 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-482 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-532
Ookinete numbers (in vitro) reduced to 52% of wild type
Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-482 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-532
Oocyst numbers (day 12-14) reduced to 20% of wild type
Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-482 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-532 Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-482
Normal numbers of salivary gland sporozoites are produced. Sporozoites showed reduced gliding motility and cell traversal capacity in vitro. Invasion of HepG2 cells in vitro was comparable to that of wild type parasites. Infectivity of sporozoites to mice was strongly reduced (as tested by intravenous injection of purified sporozoites or after infection of mice by mosquito bite). Salivary gland sporozoites show premature development into early liver stage forms (see further 'Additional remarks phenotype')
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-532
transmitted by mosquito bite
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-482
Sporozoites showed reduced gliding motility and cell traversal capacity in vitro. Invasion of HepG2 cells in vitro was comparable to that of wild type parasites. Infectivity of sporozoites to mice was strongly reduced (as tested by intravenous injection of purified sporozoites or after infection of mice by mosquito bite). Salivary gland sporozoites show premature development into early liver stage forms (see further 'Additional remarks phenotype')
Imported from RMgmDB

More information

PlasmoDB PF3D7_0107600
GeneDB PF3D7_0107600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL1P2.04, PFA0380w
Orthologs PBANKA_0205800 , PCHAS_0204200 , PY17X_0207200
Google Scholar Search for all mentions of this gene