Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) Imported from PlasmoGEM

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Right: Expression of P. falciparum centrin in schizonts. P. falciparum parasites were probed against mouse anti-PfCEN1, -2, -3, and -4 antibodies. Centrins are associated with the mitotic spindle.Left: Immunoelectron micrograph showing reactivity with the P. falciparum centrin-2 antibody. The gold particles associated with the nucleus of P. falciparum sporozoite stage parasite (A) and nucleus of asexual blood stage schizonts (B). N, nucleus; PVM, parasitophorous vacuole membrane; RBC, red blood cell. In sporozoites, IEM localization of PfCEN2 was observed as multiple dots in an area surrounding the nucleus suggesting a possible association with the centrosome. Similarly, in blood form schizonts, immunogold particles were seen to be associated with an area in proximity to the nucleus.Mahajan B, Selvapandiyan A, Gerald NJ, Majam V, Zheng H, Wickramarachchi T, Tiwari J, Fujioka H, Moch JK, Kumar N, Aravind L, Nakhasi HL, Kumar S. Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum. J Biol Chem. 2008 283:31871-83.

See original on MMP

Expression of P. falciparum centrin in schizonts. P. falciparum parasites were probed against mouse anti-PfCEN1, -2, -3, and -4 antibodies. Centrins are associated with the mitotic spindle. Immunoelectron micrograph showing reactivity with the P. falciparum centrin-2 antibody. The gold particles associated with the nucleus of P. falciparum sporozoite stage parasite (A) and nucleus of asexual blood stage schizonts (B). N, nucleus; PVM, parasitophorous vacuole membrane; RBC, red blood cell. In sporozoites, IEM localization of PfCEN2 was observed as multiple dots in an area surrounding the nucleus suggesting a possible association with the centrosome. Similarly, in blood form schizonts, immunogold particles were seen to be associated with an area in proximity to the nucleus.Mahajan B, Selvapandiyan A, Gerald NJ, Majam V, Zheng H, Wickramarachchi T, Tiwari J, Fujioka H, Moch JK, Kumar N, Aravind L, Nakhasi HL, Kumar S. Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum. J Biol Chem. 2008 283:31871-83.

See original on MMP

More information

PlasmoDB PF3D7_0107000
GeneDB PF3D7_0107000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) MAL1P1.61, PFA0345w
Orthologs PBANKA_0206300 , PCHAS_0204700 , PKNH_0206500 , PVP01_0207800 , PVX_081420 , PY17X_0207700
Google Scholar Search for all mentions of this gene