Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-560 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM

Imaging data (from Malaria Metabolic Pathways)

(C) and confocal and (D) localization of PfGSK3-GFP in late trophozoites (LT) schizonts (S) and merozoites (M) revealed perinuclear and cytosolic distribution. Nuclei are stained with DAPI (blue). localization studies indicate that the kinase localizes in nuclear or perinuclear compartments as well as in the cytosol in erythrocytic stages of the parasite.Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW. Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites. Sci Rep. 2016 6:34479.

See original on MMP

More information

PlasmoDB PCHAS_1416300
GeneDB PCHAS_1416300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000418.03.0, PCAS_141630, PCHAS_141630
Orthologs PBANKA_1414500 , PF3D7_1316000 , PKNH_1416700 , PVP01_1416900 , PVX_122625 , PY17X_1416200
Google Scholar Search for all mentions of this gene