Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-787 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-785 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-787 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-785 Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-787 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-785 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-787
Normal gametocyte production. Normal gamete formation (exflagellation). Aberrant development of ookinetes. Development of the zygote through stages IIII of ookinete maturity (09 h post-fertilisation)was indistinguishable in the ppkl- mutants compared to wild-type. Wild-type controls showed normal progression and maturation to stage IV (at 12 h), with 69% of all macrogamete-derived parasites progressing to stage VI 24 h post-fertilisation. In contrast, the majority of ppkl2 mutants did not progress from stage III to stage IV, but produced a high proportion of abnormal retort forms 24 h post fertilisation (35% of the total population) with only 4% progressing to stage IVVI.Ookinetes are affected in motility and migration through the midgut wall
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-785
Normal gametocyte production. Normal gamete formation (exflagellation). Aberrant development of ookinetes.Differentiation of female gametes into ookinete stages was severely impaired producing abnormal forms, with 63% appearing as retort-shaped forms (the Type III form).Ookinetes are affected in motility
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-787
No oocyst formation. Ookinetes are affected in motility and migration through the midgut wall
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-785
No oocyst formation. Ookinetes are affected in motility and migration through the midgut wall
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-787
No oocyst formation and not sporozoite formation
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-785
No oocyst formation and sporozoite formation
Imported from RMgmDB

More information

PlasmoDB PCHAS_1334100
GeneDB PCHAS_1334100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000764.04.0, PC300685.00.0, PCAS_133410, PCHAS_133410
Orthologs PBANKA_1329500 , PF3D7_1466100 , PKNH_1215400 , PVP01_1240700 , PVX_117160 , PY17X_1334200
Google Scholar Search for all mentions of this gene