Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-4128 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-4128 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4128
Normal numbers of oocysts produced. Normal numbers of midgut sporozoites inside oocysts. Reduced numbers of hemolymph sporozoites and no salivary gland sporozoites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4128
Normal numbers of oocysts produced. Normal numbers of midgut sporozoites inside oocysts. Reduced numbers of hemolymph sporozoites and no salivary gland sporozoites. Reduced egress of sporozoites from oocysts. Sporozoites are immotile inside and outside oocysts.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4128
No infection of hepatocytes in vitro or mice by sporozoites isolated from midguts.
Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Protein expression profile of selected P. falciparum proteases. IFAs using polyclonal mouse antisera directed against 12 of the proteases was used to demonstrate protein expression in the asexual blood stages (R, ring; T, trophozoite; iS, immature schizont; mS, mature schizont) and gametocytes (GC stages III, IV and V) as well as in macrogametes (MaG) at 20 min post-activation (in green). The asexual and the sexual blood sstages were visualized via immunolabelling with polyclonal rabbit antisera against PfMSP1 and Pfs230, respectively (in red). Hoechst 33342 staining was used to highlight the parasite nuclei (in blue). Bar, 5 μm. Results are representative of three to four independent experiments.Weißbach T, Golzmann A, Bennink S, Pradel G, Julius Ngwa C. Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum. Exp Parasitol. 2017 Mar 25. [Epub ahead of print]

See original on MMP

More information

PlasmoDB PCHAS_1333700
GeneDB PCHAS_1333700
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000443.00.0, PCAS_133370, PCHAS_133370
Orthologs PBANKA_1329100 , PF3D7_1465700 , PKNH_1215800 , PVP01_1241100 , PVX_117180 , PY17X_1333800
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