Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4173 Imported from RMgmDB
P. falciparum 3D7
Possible
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4173 Imported from RMgmDB
P. falciparum 3D7 Asexual
No difference
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Gametocyte
No difference
RMgm-4173 Imported from RMgmDB
P. falciparum 3D7 Gametocyte
No difference
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Ookinete
No difference
RMgm-4173 Imported from RMgmDB
P. falciparum 3D7 Ookinete
Attenuated
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4173
Normal ookinete production. Normal ookinete motility. Significantly reduced oocyst numbers/production.
Imported from RMgmDB
P. falciparum 3D7 Oocyst
Attenuated
29873127
No deficiency in the ability of ∆SOPT parasites to differentiate into gametes/zygotes, retorts or ookinetes compared to NF54. However, when midguts were dissected one-week post mosquito infection, a significant reduction in oocyst numbers was observed for ∆SOPT mutants compared to NF54. The number of salivary gland sporozoites was also reduced in mosquitoes fed ∆SOPT parasites compared to NF54, a phenotype that is expected based on the reduction in oocysts.
Theo Sanderson, Wellcome Trust Sanger Institute
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-4173
Normal ookinete production. Significantly reduced oocyst numbers/production.Significantly reduced salivary gland numbers/production. Sporozoites were infective to mice as shown by bite-back experiments
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4173
Significantly reduced salivary gland numbers/production. Sporozoites were infective to mice as shown by bite-back experiments
Imported from RMgmDB

More information

PlasmoDB PCHAS_1106600
GeneDB PCHAS_1106600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC001277.02.0, PCAS_110660, PCHAS_110660
Orthologs PBANKA_1106900 , PF3D7_0507300 , PKNH_1026300 , PVP01_1026700 , PVX_097925 , PY17X_1108000
Google Scholar Search for all mentions of this gene