Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Refractory
36511651 (Knock down)
\". GlmS-ribozyme mediated inducible knockdown (iKD) showed its 15 indispensability for the asexual blood stages of the parasite. The protein was found to be 16 associated with ER, and its inducible knockdown disrupted ER morphology and 17 development . Further, the iKD of PfUSP increased DHA sensitivity and polyubiquitination of 18 specific parasite proteins, suggesting its role in protein homeostasis and drug-induced stress 19 tolerance. T\"
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PCHAS_1002000
GeneDB PCHAS_1002000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC300262.00.0, PCAS_100100, PCHAS_100200
Orthologs PBANKA_1001100 , PF3D7_0403500 , PKNH_0301300 , PVP01_0302700 , PVX_001075 , PY17X_1002500
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