Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Localisation of PfFtsH1 in a P. falciparum 3D7 transfectant line carrying C-terminal 3xHA-tagged PfFtsH1. (B) Immunofluorescence localization of PfFtsH1-HA using the anti-HA mAb and antibody against the apicoplast marker ACP. No overlap of PfFtsH1-HA signal was observed with the apicoplast marker. (C) PfFtsH1 co-localizes with the mitochondrial signal in trophozoites (upper panel) and appears as punctuate signals lining the organelle defined by the mitochondrial stain Mitotracker Red in schizonts (lower panel). (D) Confocal microscopy PfFtsH1-HA expressing parasites showing co-localisation of PfFtsH1 with the mitochondrion which is stained with Mitotracker Red. clear overlap was observed between the PfFtsH1-HA signal and the mitochondria-specific dye Mitotracker Red. When the mitochondria elongated and branched in the schizont stages, punctuate signals of PfFtsH1-HA were seen along the length of the organelle (C, lower panel).Tanveer A, Allen SM, Jackson KE, Charan M, Ralph SA, Habib S. An FtsH Protease Is Recruited to the Mitochondrion of Plasmodium falciparum. PLoS One. 2013 Sep 13;8(9):e74408.

See original on MMP

More information

PlasmoDB PCHAS_0915800
GeneDB PCHAS_0915800
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000187.04.0, PC000425.02.0, PC300501.00.0, PCAS_091580, PCHAS_091580
Orthologs PBANKA_0928500 , PF3D7_1119600 , PKNH_0917300 , PVP01_0920200 , PVX_091615 , PY17X_0930500
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