Normal production of gametocytes; normal activation, gamete formation and egress of gametocytes/gametes from host red blood cells. No ookinete formation in vitro. Crossing experiments with mutants defective in either male or female gamete production showed that PDI-Trans female gametes are fertile while PDI-Trans male gamete fertility is strongly reduced.

Normal production of gametocytes; normal activation, gamete formation and egress of gametocytes/gametes from host red blood cells. No ookinete formation in vitro. Crossing experiments with mutants defective in either male or female gamete production showed that PDI-Trans female gametes are fertile while PDI-Trans male gamete fertility is strongly reduced. Strongly reduced oocyst formation (63-96% inhibition) of oocyst formation

Strongly reduced oocyst formation (63-96% inhibition) of oocyst formation; the small number of oocysts formed are morphologically normal and form normal sporozoites that are infective to mice.

Strongly reduced oocyst formation (63-96% inhibition) of oocyst formation; the small number of oocysts formed are morphologically normal and form normal sporozoites that are infective to mice.