Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-165 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-168 Imported from RMgmDB
P. berghei ANKA
Possible
RMgm-154 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. yoelii yoelii 17X
Possible
RMgm-4070 Imported from RMgmDB
P. yoelii yoelii 17X
Possible
RMgm-4453 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-165 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-168 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
RMgm-154 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. yoelii yoelii 17X Asexual
No difference
RMgm-4070 Imported from RMgmDB
P. yoelii yoelii 17X Asexual
No difference
RMgm-4453 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-165 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-168 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-154 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-4070 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
No difference
RMgm-4453 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-165
Normal numbers of ookinetes are produced. These ookinetes have a (light microscope) morphology that is comparable to wild type ookinetes. Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. Ookinetes fail to invade midgut epithelial cells. Electron microscopic analyses demonstrated that the disruptant ookinetes could not access midgut epithelial cells by traversing the layer covering the cell surface.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-168
Normal numbers of ookinetes are produced. These ookinetes have a (light microscope) morphology that is comparable to wild type ookinetes. Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. Ookinetes fail to invade midgut epithelial cells. Ookinetes are severely impaired in the ability to migrate in vitro through a gel structure (Matrigel; see 'Additional information'). Ookinetes were able to move on the gel surface.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-154
Normal numbers of ookinetes are produced. These ookinetes have a (light microscope) morphology that is comparable to wild type ookinetes. Ookinetes show a strong reduction (98%) in the formation of oocysts in A. stephensi mosquitoes. Ookinetes fail to associate with the midgut epithelium. Ookinetes showed a strongly reduced ability to glide productively.
Imported from RMgmDB
P. yoelii yoelii 17X Ookinete
Difference from wild-type
RMgm-4070
Ookinetes show strongly reduced forward gliding
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-165
Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. The few oocysts that are produced, form normal numbers of sporozoites that are infectious to the mammalian host as determined by intravenous inoculation of sporozoites in rats.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-168
Ookinetes show a strong reduction (99%) in the formation of oocysts in A. stephensi mosquitoes. The few oocysts that are produced, form normal numbers of sporozoites that are infectious to the mammalian host as determined by intravenous inoculation of sporozoites in rats.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-154
Ookinetes show a strong reduction (98%) in the formation of oocysts in A. stephensi mosquitoes. Injection of in vitro cultured, mature ookinetes into the hemocoel and thereby by-passing the midgut wall resulted in normal development of oocysts and infectious sporozoites.
Imported from RMgmDB
P. yoelii yoelii 17X Oocyst
Difference from wild-type
RMgm-4070
Ookinetes show strongly reduced forward gliding. No oocyst are formed.
Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-165 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-168 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-154 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-168 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-165 Imported from RMgmDB
P. berghei ANKA Liver
No difference
RMgm-154 Imported from RMgmDB

More information

PlasmoDB PCHAS_0409100
GeneDB PCHAS_0409100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PC000360.03.0, PC000479.04.0, PC300912.00.0, PCAS_040910, PCHAS_040910
Orthologs PBANKA_0408200 , PF3D7_0310100 , PKNH_0832600 , PVP01_0830100 , PVX_119610 , PY17X_0410700
Google Scholar Search for all mentions of this gene