Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
RMgm-545 Imported from RMgmDB
P. falciparum 3D7
Refractory
22127061 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Immunofluorescence studies performed using anti-PfPKB antisera on thin blood smears of P. falciparum cultures revealed that only late schizonts but no other asexual stages (Hoechst-stained) were recognized by this anti-sera. Upper row: Rabbit antisera against PfPKB (red) and mouse antisera against MSP1 (green) was used to localize these proteins in late/segmented schizonts, or in free merozoites (lower row). The right panel in the lower row shows a zoomed image of merozoites stained with MSP1 and PfPKB antisera. PfPKB exhibited a diffused staining pattern in segmented schizonts, indicating its presence in the cytoplasm, and also exhibited some co-localization with MSP1. In free merozoites PfPKB seems to be localized at the apical end.Kumar A, Vaid A, Syin C, Sharma P. PfPKB, a novel protein kinase B-like enzyme from Plasmodium falciparum: I. Identification, characterization, and possible role in parasite development. J Biol Chem. 2004 279:24255-64.

See original on MMP

More information

PlasmoDB PBANKA_1460000
GeneDB PBANKA_1460000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000522.03.0, PB405446.00.0, PBANKA_146000, PbPKB
Orthologs PCHAS_1462300 , PF3D7_1246900 , PKNH_1466600 , PVP01_1464000 , PVX_101240 , PY17X_1462600
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