Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
RMgm-5031 Imported from RMgmDB
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-5031 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
Two independent parasite clones, in which the RvBL1 gene was disrupted produced mature-appearing females and males. However, both clones lacked exflagellation.
Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Localization of RuvB1 in P. falciparum during erythrocytic cycle by immunofluorescence staining coupled immunofluorescence microscopy. Different stages of the P. falciparum 3D7 strain parasite i.e. ring, trophozoites, schizonts and merozoites were labeled with purified anti-PfRuvB1 antibodies. The cells were fixed and immunostained. Panels (i) bright field image, (ii) image of cell stained with DAPI, (iii) immunofluorescently stained cell (green, P. falciparum RuvB1 protein) and (iv) super-imposed images. RuvB1 is expressed during all the stages. RuvB1 localized to the nuclear region and co-localizes with the DAPI in ring and trophozoite as well as schizont stage. Ahmad M, Tuteja R. Plasmodium falciparum RuvB1 is an active DNA helicase and translocates in the 5'-3' direction. Gene. 2013 Feb 15;515(1):99-109

See original on MMP

More information

PlasmoDB PBANKA_1427700
GeneDB PBANKA_1427700
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000515.01.0, PB300634.00.0, PBANKA_142770
Orthologs PCHAS_1429500 , PF3D7_0809700 , PKNH_1431000 , PVP01_1430600 , PVX_123295 , PY17X_1429800
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