Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1133 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
RMgm-1133
Reduced growth of asexual blood stages
Imported from RMgmDB
P. berghei ANKA Asexual
Attenuated
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-1133 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-1133 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-1133 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-1133 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1133
Normal numbers of salivary gland sporozoites. Reduced infectivity of sporozoites to mice. Evidence is presented for normal liver infection but affected late liver development. Mutant liver stages in culture showed a small, albeit significant, size reduction at 48h but the number of EEFs was very similar to wild type cultures. Mutant infected hepatoma cells produced two-fold fewer merosomes as compared to wild type.
Imported from RMgmDB

More information

PlasmoDB PBANKA_1404100
GeneDB PBANKA_1404100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000986.02.0, PBANKA_140410
Orthologs PCHAS_1406000 , PF3D7_1305600 , PKNH_1405800 , PVP01_1406500 , PVX_122115 , PY17X_1405800
Google Scholar Search for all mentions of this gene