Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1379 Imported from RMgmDB
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-1379 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-1379 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-1379
Oocyst development delayed
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1379
Strongly reduced sporozoite numbers in vivo with a strong developmental delay
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1379
No transmission by bite of infected mosquitoes
Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Immunolocalization of a putative P. falciparum copper transport protein. Asexual P. falciparum parasites were grown in vitro, synchronized by sorbitol treatment and samples removed at five time points (A – E). Fixed parasites were probed with chicken antipeptide antibodies targeting PF14_0369 and rabbit antibodies against Exp-1. Chicken antibodies were detected with a Cy3-conjugated antibody and rabbit antibodies with a Cy2-conjugated antibody. Panels are representative of the following stages of asexual parasite development: A. early rings; B. late rings; C. early trophozoites; D. late trophozoites; E. schizonts. Parasite DNA was stained with Hoechst. Scale bar is 5 μm.Choveaux DL, Przyborski JM, Goldring JD. A Plasmodium falciparum copper-binding membrane protein with copper transport motifs. Malar J. 2012 11(1):397.

See original on MMP

Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization. Shown are proteins that revealed cytosolic (PFC0945w, PFI1565w’PF11_0190 and PFL2100w, apicoplast (PFE0145w), mitochondrial and other subcellular distribution but may be involved in invasion.Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.

See original on MMP

More information

PlasmoDB PBANKA_1302900
GeneDB PBANKA_1302900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000039.01.0, PBANKA_130290
Orthologs PCHAS_1306100 , PF3D7_1439000 , PKNH_1243300 , PVP01_1268000 , PVX_118540 , PY17X_1306700
Google Scholar Search for all mentions of this gene