Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Refractory
37596377 (Conditional)
Essential for merozoite invasion. Delay in gam formation. DiCre approach
Theo Sanderson, Francis Crick Institute
P. falciparum 3D7 Gametocyte
Difference from wild-type
37596377 (Conditional)
Essential for merozoite invasion. Delay in gam formation. DiCre approach
Theo Sanderson, Francis Crick Institute

Imaging data (from Malaria Metabolic Pathways)

Schizont and merozoite culture was incubated overnight with 0.1µM cytochalasin D to inhibit invasion. Thin smeared on a glass slide, fixed in methanol, stained with Rabbit anti-formin1 polyclonal serum 1:300. Formin1 localizes to extreme apex of merozoite and follows tight junction (not shown).Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB, Richard D, Pollard TD, Cowman AF. A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion. Cell Host Microbe. 2008 3:188-98. Copyright Elsevier 2009.

See original on MMP

More information

PlasmoDB PBANKA_1245300
GeneDB PBANKA_1245300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000518.00.0, PB000969.00.0, PB400014.00.0, PBANKA_124530
Orthologs PCHAS_1245700 , PF3D7_0530900 , PKNH_1001800 , PVP01_1002900 , PVX_079720 , PY17X_1248800
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