Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. yoelii yoelii 17X
Possible
RMgm-4785 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. yoelii yoelii 17X Asexual
No difference
RMgm-4785 Imported from RMgmDB
P. yoelii yoelii 17X Gametocyte
Difference from wild-type
RMgm-4785
normal production of gametocytes; reduced exflagellation
Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Several IMC proteins co-localize with GAP45 during schizogony. (A) Using GFP as a fluorescence tag, the TMD proteins PFE1130w, MAl13P1.130, PFD1110w, as well as PF14_0578 reveal three distinct structures during ongoing schizogony. Commencing as cramplike structures (T1), they transform to small ring-shaped formations (T2) that toward the end of schizogony expand and are then equally distributed underneath the plasma membrane (T3). Enlargement of these distinct structures are marked (white square) and shown in second row (Zoom) for each cell line.Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielmann T, Parkinson J, Gilberger TW. Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite. Mol Biol Evol. 2012 Sep;29(9):2113-32. PMID:

See original on MMP

Subcellular distribution of proteins predicted to be involved in invasion. All proteins were localized in schizonts (s) and free merozoites (m) using GFP-fusion proteins and grouped according to their predominant GFP localization: surface (green), inner membrane complex (turquoise),Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z. Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol. 2010 28(1):91-8.

See original on MMP

More information

PlasmoDB PBANKA_1237300
GeneDB PBANKA_1237300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000105.02.0, PBANKA_123730
Orthologs PCHAS_1237800 , PF3D7_0522600 , PKNH_1010300 , PVP01_1011300 , PVX_080120 , PY17X_1240600
Google Scholar Search for all mentions of this gene