Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-328 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-328 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-328 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-328
Normal rate of fertilization and ookinete production. Ookinetes showed reduced motility. Mutant ookinetes showed an average speed of 3.7 m/min and wild type ookinetes an average speed of 6.5 m/min. Mutant ookinetes transiently showed fast locomotion comparable to wild type.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-328
Strongly reduced oocyst formation in Anopheles stephensi mosquitoes, both after feeding mosquitoes on infected mice and by membrane feeding of in vitro cultured mature ookinetes to mosquitoes. The oocysts formed, produced normal numbers of sporozoites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-328
Sporozoites have lost the ability to invade salivary glands. Midgut-associated sporozoites were non-infectious to mice after intravenous injection. Sporozoites showed strongly reduced motility and never displayed productive (forward) locomotion.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-328
Midgut-associated sporozoites were non-infectious to mice after intravenous injection.
Imported from RMgmDB

More information

PlasmoDB PBANKA_1232400
GeneDB PBANKA_1232400
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) CPbeta, PB000641.00.0, PBANKA_123240
Orthologs PCHAS_1233000 , PF3D7_0517600 , PKNH_1015700 , PVP01_1016400 , PVX_080370 , PY17X_1235800
Google Scholar Search for all mentions of this gene