Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
36625569 (Knock down)
From Fig S4, little effect if any on basic growth. \'A Western blot analysis of the proteins from GlcN-treated pSLI-HA-NeoR-glmS-tagged (PfRFULg) parasites, relative to their wild-type (Dd2) controls, showed changes in the ubiquitination of numerous proteins. PfRFUL KD rendered the parasites more sensitive to multiple antimalarial drugs, including mefloquine, piperaquine, amodiaquine, and dihydroartemisinin. PfRFUL KD also decreased the protein level of the P. falciparum multiple drug resistance 1 protein (PfMDR1) and altered the ratio of two bands of the P. falciparum chloroquine resistance transporter (PfCRT), suggesting contributions to the changed drug responses by the altered ubiquitination of these two molecules. \'
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PBANKA_1202600
GeneDB PBANKA_1202600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000859.01.0, PB300110.00.0, PBANKA_120260
Orthologs PCHAS_1203300 , PF3D7_1004300 , PKNH_0803000 , PVP01_0804000 , PVX_094410 , PY17X_1205700
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