Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
RMgm-1054 Imported from RMgmDB
P. berghei ANKA
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
RMgm-4640 Imported from RMgmDB
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-4640 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
Normal (wild type) numbers of male and female gametocytes produced. Strong reduction in male gamete formation (exflagellation): 13.8 25% exflagellating pbpp5 male gametocytes compared with 88.9% in wild type parasites.
Imported from RMgmDB

Imaging data (from Malaria Metabolic Pathways)

Stage specific expression and intracellular localisation. Indirect immunofluorescence analysis was performed on thin smears of mixed P. falciparum cultures to localise PfPP5. Different stages were observed under a ZEISS fluorescence microscope with interference contrast, with the FITC channel for detection of PfPP5 and with the DAPI channel to visualise DNA. Both FITC and DAPI images were merged to show concordance. PfPP5 appears to be concentrated in the nucleus, as evidenced by its colocalisation innuclear material as counterstained with the dye DAPI. However, the protein is also detectable in the cytoplasm of P. falciparum although in a lower concentrationLindenthal C, Klinkert MQ. Identification and biochemical characterisation of a protein phosphatase 5 homologue from Plasmodium falciparum. Mol Biochem Parasitol. 2002 120(2):257-68.

See original on MMP

More information

PlasmoDB PBANKA_1131900
GeneDB PBANKA_1131900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000597.03.0, PB001029.01.0, PBANKA_113190
Orthologs PCHAS_1131400 , PF3D7_1355500 , PKNH_1116000 , PVP01_1116400 , PVX_114750 , PY17X_1133400
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