Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4937 Imported from RMgmDB
P. yoelii yoelii 17X
Possible
RMgm-1413 Imported from RMgmDB

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4937 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-4937 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-4937 Imported from RMgmDB
P. berghei ANKA Oocyst
No difference
RMgm-4937 Imported from RMgmDB
P. berghei ANKA Sporozoite
No difference
RMgm-4937 Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-4937
Normal infectivity of sporozoites to hepatocytes in vitro and in vivo. Mutant parasites develop into large, mature liver stages with extensive nuclear division and expression of merozoite specific proteins, such as msp1 and ama1. Most of the parasites arrest growth, however, just before the formation of infective merozoites. Only after intravenously infection of mice with high doses of sporozoites (2x10(5)) some of the mice (3 out of 10) developed blood infections with a greatly prolonged prepatent period (12-14 days).
Imported from RMgmDB
P. yoelii yoelii 17X Asexual
No difference
RMgm-1413 Imported from RMgmDB
P. yoelii yoelii 17X Sporozoite
No difference
RMgm-1413 Imported from RMgmDB
P. yoelii yoelii 17X Liver
Difference from wild-type
RMgm-1413
Plasmei2 sporozoites failed to initiate a blood stage infection (after injection of 5x10(4) purified sporozoites). Abnormal development of liver stages. Growth arrest of late liver stages.
Imported from RMgmDB

More information

PlasmoDB PBANKA_1122300
GeneDB PBANKA_1122300
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB001281.02.0, PBANKA_112230
Orthologs PCHAS_1121800 , PF3D7_0623400 , PKNH_1126800 , PVP01_1126100 , PVX_114285 , PY17X_1123700
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