Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Refractory
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen
P. falciparum 3D7
Refractory
32552779
Initial attempt to generate frameshift with CRISPR failed
Theo Sanderson, Francis Crick Institute

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. falciparum 3D7 Asexual
Attenuated
32552779 (Knock down)
"The growth of more than 50% of the PfArp4-Ty1-Ribo parasites was arrested when the PfArp4 protein was downregulated". "Consistent with the results of the growth curve analysis, western blot (WB) analysis showed that the expression level of the PfArp4 protein was significantly reduced in the trophozoite stage parasites when GlcN was present in the culture (Fig. 1e). An abnormal morphology was also observed in the trophozoite-stage parasites of the PfArp4-Ty1-Ribo line treated with GlcN after one cell cycle".
Theo Sanderson, Francis Crick Institute

More information

PlasmoDB PBANKA_1020600
GeneDB PBANKA_1020600
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000458.02.0, PBANKA_102060
Orthologs PCHAS_1021400 , PF3D7_1422800 , PKNH_1335200 , PVP01_1326200 , PVX_085340 , PY17X_1022500
Google Scholar Search for all mentions of this gene