Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-4686 Imported from RMgmDB
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-4686 Imported from RMgmDB
P. berghei ANKA Gametocyte
Difference from wild-type
RMgm-4686
Normal number of gametocytes and gametes were formed. The pb115 parasites showed significant defects in the interactions between the male and female gametes, and as a result, very few zygotes were formed in ookinete cultures.
Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-4686
During our in vitro culture of ookinetes, the zygote numbers formed at 2 h and ookinete numbers at 24 h in the two pb115 clones suffered similar levels of reduction (95%) compared to the WT parasites. The pb115 parasites showed significant defects in the interactions between the male and female gametes, and as a result, very few zygotes were formed in ookinete cultures.
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-4686
Mosquitoes fed on pb115-infected mice showed 74% reduction in the prevalence of infection and 96.5% reduction in oocyst density compared to those fed on wild-type P. berghei-infected mice
Imported from RMgmDB

More information

PlasmoDB PBANKA_0931000
GeneDB PBANKA_0931000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000712.03.0, PB300324.00.0, PBANKA_093100
Orthologs PCHAS_0913300 , PF3D7_1117000 , PKNH_0914700 , PVP01_0917600 , PVX_091480 , PY17X_0933000
Google Scholar Search for all mentions of this gene