Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-801 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-801 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Gametocyte
No difference
RMgm-801 Imported from RMgmDB
P. berghei ANKA Ookinete
Difference from wild-type
RMgm-801
Normal ookinete production in vitro. Light microscope morphology of mature ookinetes normal. Nuclei of mutant ookintes were different from those of wild type ookinetes at the electron microscope level (see 'Additional information phenotype')
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-801
Normal ookinete production in vitro. Mutant parasites produced 50-80% less oocysts. Mutant oocysts were smaller compared to wild type oocysts (see also 'Additional information phenotype'). Mutant oocysts produced 30-fold lower midgut sporozoites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-801
Mutant parasites produced 50-80% less oocysts. Mutant oocysts were smaller compared to wild type oocysts. Mutant oocysts produced 30-fold lower midgut sporozoites and 20-fold lower numbers of salivary gland sporozoites (day 21 after infection). Mutant sporozoites are not infective to mice.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-801
Mutant oocysts produced 30-fold lower midgut sporozoites and 20-fold lower numbers of salivary gland sporozoites (day 21 after infection). Mutant sporozoites are not infective to mice.
Imported from RMgmDB

More information

PlasmoDB PBANKA_0714000
GeneDB PBANKA_0714000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000874.00.0, PB301498.00.0, PBANKA_071400
Orthologs PCHAS_0723100 , PF3D7_0816800 , PKNH_0503600 , PVP01_0518500 , PVX_089570 , PY17X_0714200
Google Scholar Search for all mentions of this gene