Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
RMgm-4191 Imported from RMgmDB
P. falciparum 3D7
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
Difference from wild-type
Growth and multiplication of blood stages in mice comparable to wild type parasites. Normal virulence.
Imported from RMgmDB
P. falciparum 3D7 Asexual
No difference
https://www.nature.com/articles/ncomms16044 (Knock down)
Normal growth rate upon glmS KD
Theo Sanderson, Wellcome Trust Sanger Institute

Imaging data (from Malaria Metabolic Pathways)

Proteins with TM that are located in the PV. Live cell microscopy images of the endogenously GFP-tagged alkaline phosphatase and EXP3. Left panel: a young and an old schizont are shown to illustrate the change from a staining surrounding the bulk of the still forming merozoites (third row of images) to a ‘bunch of grape’ type pattern where each merozoite is surrounded by GFP signal after the PPM is invaginated (bottom row of images). Right panel: a late trophozoite (third row of images), a young schizont (fourth row of images) and a late schizont (bottom row of images) are shown to demonstrate the change from a peripheral to a parasite internal staining .Khosh-Naucke M, Becker J, Mesén-Ramírez P, Kiani P, Birnbaum J, Fröhlke U, Jonscher E, Schlüter H, Spielmann T. Identification of novel parasitophorous vacuole proteins in P. falciparum parasites using BioID. Int J Med Microbiol. 2017 Jul 27. [Epub ahead of print]

See original on MMP

More information

PlasmoDB PBANKA_0509000
GeneDB PBANKA_0509000
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000060.02.0, PB000714.03.0, PBANKA_050900
Orthologs PCHAS_0509100 , PF3D7_1024800 , PKNH_0609300 , PVP01_0610000 , PVX_111470 , PY17X_0510100
Google Scholar Search for all mentions of this gene