Disruptability [+]

Species Disruptability Reference Submitter
P. falciparum 3D7
Possible
18614010 Theo Sanderson, Wellcome Trust Sanger Institute
P. falciparum 3D7
Possible
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

None reported yet. Please press the '+' button above to add one.

Imaging data (from Malaria Metabolic Pathways)

Fluorescent images of P. falciparum schizonts labelled with an antibody to cytoplasmic dynein heavy chain (green) (i), overlaid with images of the DAPI-staining of nuclei (blue) (ii), and the DIC image (iii). Plates (iv) show the DIC image alone. In plate A(i) an early schizont, with four nuclei, shows dynein labelling peripheral to the parasite nuclei (ii) and following the outline of the parasite cell body, seen in the DIC image (iv). In plate B(i) a later schizont, with 10 nuclei, shows dynein labelling, again concentrated at the periphery of the parasite. In plate C(i) a parasite with a full complement of 16 nuclei, shows less intense dynein labelling, with small points of fluorescence apparent throughout the parasite. In plate D(i) a parasite which is in the process of merozoite budding, as evident from the DIC picture (iv), and has lost its host cell membrane, shows distinct crescents of dynein labelling associated with each merozoite nucleus (ii) and the budding merozoite apices (iii).Fowler RE, Smith AM, Whitehorn J, Williams IT, Bannister LH, Mitchell GH. Microtubule associated motor proteins of Plasmodium falciparum merozoites. Mol Biochem Parasitol. 2001 117:187-200.

See original on MMP

More information

PlasmoDB PBANKA_0416100
GeneDB PBANKA_0416100
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000358.03.0, PB000791.03.0, PB001159.02.0, PBANKA_041610
Orthologs PCHAS_0417000 , PF3D7_0905300 , PKNH_0703000 , PVP01_0703700 , PVX_098710 , PY17X_0418900
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