Disruptability [+]

Species Disruptability Reference Submitter
P. berghei ANKA
Possible
RMgm-1376 Imported from RMgmDB
P. berghei ANKA
Possible
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA
Possible
RMgm-5234 Imported from RMgmDB
P. falciparum 3D7
Refractory
USF piggyBac screen (Insert. mut.) USF PiggyBac Screen

Mutant phenotypes [+]

Species Stage Phenotype Reference Submitter
P. berghei ANKA Asexual
No difference
RMgm-1376 Imported from RMgmDB
P. berghei ANKA Asexual
No difference
PlasmoGEM (Barseq) PlasmoGEM
P. berghei ANKA Asexual
No difference
RMgm-5234 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-1376 Imported from RMgmDB
P. berghei ANKA Gametocyte
No difference
RMgm-5234 Imported from RMgmDB
P. berghei ANKA Ookinete
No difference
RMgm-5234 Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-1376
Oocyst development delayed
Imported from RMgmDB
P. berghei ANKA Oocyst
Difference from wild-type
RMgm-5234
Wildtype-like oocyst production. Evidence is presented for a reduced (delayed) egress of sporozoites from the oocysts and a defect in salivary gland invasion. Strongly reduced numbers of salivary gland sporozoites.
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-1376
Strongly reduced sporozoite numbers in vivo with a strong developmental delay
Imported from RMgmDB
P. berghei ANKA Sporozoite
Difference from wild-type
RMgm-5234
Evidence is presented for a reduced (delayed) egress of sporozoites from the oocysts and a defect in salivary gland invasion. Strongly reduced numbers of salivary gland sporozoites.Mice injected with wild-type sporozoites showed a prepatent period of 4 days and 7 days for salivary glands sporozoites and hemolymph sporozoites, respectively, and they did not survive due to high parasitemia beyond days 16 and 18 post sporozoite injection, respectively. However, all mice injected with knockout sporozoites did not develop any blood-stage parasitemia till day 21 post sporozoite injection.
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-1376
No transmission by bite of infected mosquitoes
Imported from RMgmDB
P. berghei ANKA Liver
Difference from wild-type
RMgm-5234
Mice injected with wild-type sporozoites showed a prepatent period of 4 days and 7 days for salivary glands sporozoites and hemolymph sporozoites, respectively, and they did not survive due to high parasitemia beyond days 16 and 18 post sporozoite injection, respectively. However, all mice injected with knockout sporozoites did not develop any blood-stage parasitemia till day 21 post sporozoite injection.
Imported from RMgmDB

More information

PlasmoDB PBANKA_0209900
GeneDB PBANKA_0209900
Malaria Metabolic Pathways Localisation images
Pathways mapped to
Previous ID(s) PB000593.01.0, PBANKA_020990
Orthologs PCHAS_0208300 , PF3D7_0103200 , PKNH_0210300 , PVP01_0211500 , PVX_081595 , PY17X_0211300
Google Scholar Search for all mentions of this gene